The clinical manifestation of CFS includes fatigue, difficulty concentrating, headaches, sore throat, tender lymph nodes, muscle aches, joint aches, fever, difficulty sleeping, psychiatric problems (such as depression), allergies, abdominal cramps, weight loss or gain, rash, rapid pulse, chest pain, and night sweats.

For thousands of years, practitioners of Chinese medicine have believed that blockages in the body's "life energy" — chi — are responsible for illness and disease. Acupuncture and other traditional Chinese treatments seek to restore the natural flow of chi and return the body to harmony.